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CYP3A4 P450-Glo™ Assays with Luciferin-IPA: The Most Sensitive and Selective...

CYP3A4 P450-Glo™ Assays with Luciferin-IPA: The Most Sensitive and Selective Bioluminescent CYP3A4 Assay

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Abstract

Here we introduce the newest bioluminescent substrate for cytochrome 3A4, Luciferin-IPA. This new generation substrate is a highly sensitive and selective probe for detecting CYP3A4 activity. The increased sensitivity allows the research to use less CYP3A4 enzyme. The substrate can be used to detect CYP3A4 gene induction and can be multiplexed with a cell viability assay.

Cell Notes 23, 17–19.

James J. Cali, Mary Sobol, Dongping Ma, H. Testsuo Uyeda, Poncho Meisenheimer

Promega Corporation and Promega Biosciences
Publication Date: 2009

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How to Cite This Article

Cali, J. J., Sobol, M., Ma, D., Uyeda, H. T. and Meisenheimer, P. CYP3A4 P450-Glo® Assays with Luciferin-IPA: The Most Sensitive and Selective Bioluminescent CYP3A4 Assay. [Internet] 2009. [cited: year, month, date]. Available from: http://fi.promega.com/resources/pubhub/cellnotes/cyp3a4-p450-glo-assays-with-luciferin-ipa-the-most-sensitive-and-selective-bioluminescent-cyp3a4/

Cali, J. J., Sobol, M., Ma, D., Uyeda, H. T. and Meisenheimer, P. CYP3A4 P450-Glo® Assays with Luciferin-IPA: The Most Sensitive and Selective Bioluminescent CYP3A4 Assay. Promega Corporation Web site. http://fi.promega.com/resources/pubhub/cellnotes/cyp3a4-p450-glo-assays-with-luciferin-ipa-the-most-sensitive-and-selective-bioluminescent-cyp3a4/ Updated 2009. Accessed Month Day, Year.

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